By the dependence on blood circulation pressure because a threat grounds having stroke, i conducted analyses stratified from the reputation for hypertension from the standard
Neither use of potassium tablets (RR=0.78; 95% CI, 0.69 to a single.22) nor use of magnesium medications (RR=0.85; 95% CI, 0.55 to just one.32) try of likelihood of total otherwise ischemic stroke during the analyses adjusted to have decades merely, but the means to access potassium medicine became firmly inversely related immediately after changes for reputation for blood circulation pressure (RR=0.55; 95% CI, 0.thirty-five to help you 0.86). History of blood pressure level was a robust separate exposure foundation to have coronary attack (RR=2.8; 95% CI, dos.1, step 3.7) and you may was in the the means to access potassium drugs (46% of the 1248 supplement profiles have been hypertensives, compared with 19% away from nonusers). Brand new inverse connection between access to potassium supplements and you can threat of stroke in multivariate analyses try separate out-of dieting consumption away from diet, along with potassium, magnesium, and you can fiber, and you can try stronger among people that have low weight-loss consumption of potassium, magnesium, and cereal fibre. This new RR researching the major towards the bottom quintile from potassium intake was 0.39 on low tertile out-of a dietary rating, including the 3 nourishment, 0.57 between, and you can 0.86 about highest tertile. To advance test the theory which use from potassium medicine decrease the risk of coronary attack, we compared boys who said playing with capsules both in 1986 and you will 1988 that have men whom never used capsules. When you look at the six kept years of follow-up, the latest multivariate RR of complete stroke one of supplement pages is actually 0.31 (95% CI, 0.12, 0.85; P=0.02); the risk of coronary arrest was also reduced one of guys just who stated using potassium pills simply when you look at the 1986 (0.46; 95% CI, 0.22, 0.98; P=0.05) however among boys which already been providing supplements in the 1988 (1.07; 95% CI, 0.55, 2.11).
Inverse contacts anywhere between mineral consumption and you may risk of stroke was in fact seen merely certainly hypertensive boys (Data dos and you may step three ). During the analyses restricted to males delivering diuretics from the standard, by yourself or even in consolidation together with other antihypertensive medications, the new RR off stroke having profiles off potassium pills weighed against nonusers is 0.thirty-six (95% CI, 0.18, 0.72; P=0.004). One another soluble fiber and you will cereal fiber was somewhat inversely from the exposure out-of heart attack among hypertensive (RRs to have an effective ten-grams escalation in intake was 0.59 and you may 0.33, respectively) however among normotensive (RRs was basically 0.88 both for) boys.
Discussion
In this high possible studies, i discovered that people with diets highest for the potassium, cereal soluble fiber, and you will magnesium got a notably less likelihood of stroke. This type of inverse associations was indeed only partially told me from the nondietary chance situations however, have been solid and high simply among men that have identified blood pressure. Zero tall relationships have been located between intakes off sodium and you will calcium and threat of heart attack.
5 21 From inside the a great ong Japanese guys inside Hawaii, potassium intake is inversely pertaining to chance of deadly thromboembolic coronary arrest (RR toward best as opposed to the bottom quintile off consumption=0.step three, P to own development=0.002) not which have likelihood of nonfatal thromboembolic stroke (RR=0.87, P getting development=0.12). 2 Brand new poor organization that have nonfatal events isn’t contradictory which have a defensive impression, having been toned down by the mistake throughout the single 24-hour keep in mind– situated fat loss research. In randomized products, high potassium consumption have triggered small loss of blood pressure levels, specifically certainly one of hypertensive victims. 6 7 So it impression, although not, is actually small and can only partially give an explanation for good inverse connection found in this study. In addition, adjustment having standard hypertension had little effect on this new estimated RRs relevant potassium consumption to coronary attack incidence, and you can potassium intake was not a significant predictor regarding threat of hypertension inside cohort. 14 Solution mechanisms advised include the inhibition off free revolutionary creation, vascular simple muscle expansion, and you will arterial thrombosis. 22 not, these effects was indeed produced by fresh increases for the solution potassium density in the dogs, in addition to their relevance to humans try not sure. Highest potassium intake may increase serum density www.hookupdaddy.net/college-hookup-apps/, particularly if consumption is actually low otherwise sodium consumption is actually large, twenty-two and can even hence slow down the chance of hypokalemia among boys within high risk on account of diuretic treatment. Diuretic-triggered hypokalemia could raise the risk of ventricular dysrhythmia. 23 24 Even when zero enhanced mortality out-of cardiovascular illnesses and other causes are located certainly one of people with lower solution potassium in 2 earlier in the day degree, 25 twenty-six none is actually big enough in order to discover a certain connection between serum potassium and you may threat of coronary arrest.